Multifunctional magnetic nanoparticles for health applications
Title: Multifunctional magnetic nanoparticles for health applications
Description:
This activity concerns the synthesis and characterization of inorganic magnetic
nanoparticles composed by a central core
of nanosized magnetite crystals, eventually coated with a silica shell or a
silica-based vitreous matrix, functionalized
with antineoplastic drugs, fatty acid, lentivirus or antibody and decorated with
plasmonic or antibacterial nanoparticles
(e.g. gold or silver nanoparticles). The magnetic nanoparticles can be obtained by
colloidal synthesis and due to their
amorphous matrix, the external surface can be easily activated, by exposing the -SiOH
functional groups. the presence
of -SiOH group on their surface can be successfully used to graft biomolecules by
direct bonding.
These nanoparticles can be proposed for the diagnosis and the therapy of the
tumors by means of combined approaches,
such as hyperthermic treatment, phototherapy, drug delivery, gene therapy and imaging.
Picture(s)
Contact(s)
enrica.verne@polito.it
Recent reference(s)
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E. Catalano et al., BIOMED. PHYS. ENG. EXPRESS 3 (2017) 025015, doi: 10.1088 / 2057-1976 / aa62cc
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G. Muzio et al., MATERIALS SCIENCE AND ENGINEERING C 76 (2017) 439–447, doi: 10.1016/j.msec.2017.03.063
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E.Borroni et al., ACTA BIOMATERIALIA 59 (2017) 303-3016 doi: 10.1016/j.actbio.2017.07.007
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M. Miola et al., Ceramics International , 43 (2017) 15258-15265, doi.org/10.1016/j.ceramint.2017.08.063
Funding
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S. Paolo Project 2010 “Nanovettori intelligenti per la diagnosi e la terapia in Oncologia”
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AIRC project IG 2012: “Development of engineered magnetic nanoparticles for cancer therapy”
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S. Paolo Project 2013 “CSP-Torino-Piemonte”: “Development of engineered magnetic nanoparticles for targeted therapies (LV-MNPs)”