Tissue engineering and investigation of tissue-biomaterial interactions
Tissue engineering and investigation of tissue-biomaterial interactions
Description
The development of new biomaterials to accelerate healing of injured tissues is one of the missions of tissue engineering. The inherent regenerative potential of bioactive materials can be increased by incorporating appropriate biomolecules (e.g. growth factors) or ionic species that, once released in situ, can elicit a therapeutic action. In the framework of a collaboration with Dr. Saeid Kargozar (Mashhad University of Medical Sciences, iran), we are producing different glass-based biomaterials to be implanted in animal models to analyze the response of living tissues. The scope is optimizing the material design (e.g. composition, structure) to gain improved performances and beneficial effects to the patient. At present, bioactive glass granules and glass/polymer composites were exploited as smart vehicles for the local delivery of bone morphogenetic proteins able to promote osteogenesis, strontium ions that are known to decrease bone resorption, and cobalt ions having a key role in promoting angiogenesis.
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Recent reference(s)
S. Kargozar et al., Mater Sci Eng C 75 (2017) 688-698
S. Kargozar et al., Acta Biomater 58 (2017) 502-514
S. Kargozar et al., Trends Biotechnol 36 (2018) 430-444
F. Baino. Ceram Int 44 (2018) 14953-14966.
Funding